chemistry, metabolism, and toxicology of cannabis: clinical implications.

Chemistry, Metabolism, and Toxicology of Cannabis: Clinical Implications

Cannabis is one of the most widely abused substances throughout the world. The primary psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (▵(9_)THC), produces a myriad of pharmacological effects in animals and humans. Although it is used as a recreational drug, it can potentially lead to dependence and behavioral disturbances and its heavy use may increase the risk for psychotic...

Chronic toxicology of cannabis.

INTRODUCTION Cannabis is the most widely used illicit drug worldwide. As societies reconsider the legal status of cannabis, policy makers and clinicians require sound knowledge of the acute and chronic effects of cannabis. This review focuses on the latter. METHODS A systematic review of Medline, PubMed, PsychInfo, and Google Scholar using the search terms "cannabis," "marijuana," "marihuana,...

Medical Chemistry and Toxicology

3.24 Chemistry of Cannabis

3.24.1 An Introduction to the Cannabis Plant 1034 3.24.1.1 The Different Forms of Cannabis 1035 3.24.1.2 The Botany of Cannabis sativa 1035 3.24.1.3 A Short History of Cannabis 1037 3.24.1.4 Chemical Constituents of Cannabis 1038 3.24.2 Cannabinoids 1039 3.24.2.1 Cannabinoids Defined 1040 3.24.2.2 Biosynthesis of the Cannabinoids 1041 3.24.2.2.1 The acidic cannabinoids 1041 3.24.2.2.2 Occurrenc...

Clinical Chemistry Division Commission on Toxicology Subcommittee on Toxicology of Selenium*

Chairman: Y. Thomassen (Norway); Members: J. Aaseth (Norway); G. Alfthan (Finland); D. Behne (FRG); H. A. Das (Netherlands); H. T. Delves (UK); R. M. Griffin (USA); M. Ihnat (Canada); V. Iyengar (FRG); 0. A. Levander (USA); Mirna Mikac-Devic (Yugoslavia); J. Pikkarainen (Finland); Marion F. Robinson (New Zealand); M. Stoeppler (FRG); Christine D. Thomson (New Zealand); R. T. Tulley (USA); C. Ve...

The Chemistry and Toxicology of Depleted Uranium

Natural uranium is comprised of three radioactive isotopes: 238 U, 235 U, and 234 U. Depleted uranium (DU) is a byproduct of the processes for the enrichment of the naturally occurring 235 U isotope. The world wide stock pile contains some 11⁄2 million tons of depleted uranium. Some of it has been used to dilute weapons grade uranium (~90% 235 U) down to reactor grade uranium (~5% 235 U), and s...